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Cell Therapy in Kidney Transplantation / 대한이식학회지
The Journal of the Korean Society for Transplantation ; : 121-134, 2014.
Article in Korean | WPRIM | ID: wpr-86709
ABSTRACT
Current immunosuppressants have nonspecific immuosuppressive effects, and are not helpful for tolerance induction. Consequently, transplant patients cannot discontinue using them, and their nonspecific immunosuppressive effects result in many side effects, including infection and malignancy. However, most of cellular immunotherapy can have donor antigen-specific immunsuppressive effects. Therefore, cell therapy could be an alternative or adjunctive to nonspecific immunosuppressants. Polyclonal or antigen-specific Foxp3+ regulatory T cells have been actively tried for prevention of acute rejection, treatment of chronic rejection, or tolerance induction in clinical trials. Regulatory macrophages are also under clinical trials for kidney transplant patients. IL-10-secreting type 1 regulatory T cells and donor- or recipient-derived tolerogenic dendritic cells will also be used for immunoregulation in clinical trials of kidney transplantation. These cells have antigen-specific immunoregulatory effects. Mesenchymal stromal cells (MSCs) have good proliferative capacity and immunosuppressive actions independently of major histocompatibility complex; therefore, even third-party MSCs can be stored and used for many patients. Cell therapy using various immunoregulatory cells is now promising for not only reducing side effects of nonspecific immunosuppressants but also induction of immune tolerance, and is expected to contribute to better outcomes in transplant patients.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Dendritic Cells / Kidney Transplantation / T-Lymphocytes, Regulatory / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Immune Tolerance / Immunosuppressive Agents / Immunotherapy / Kidney Limits: Humans Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Tissue Donors / Dendritic Cells / Kidney Transplantation / T-Lymphocytes, Regulatory / Mesenchymal Stem Cells / Cell- and Tissue-Based Therapy / Immune Tolerance / Immunosuppressive Agents / Immunotherapy / Kidney Limits: Humans Language: Korean Journal: The Journal of the Korean Society for Transplantation Year: 2014 Type: Article