Correlation between serum CTRP3 and CTRP9 levels and glycolipid metabolism in preeclampsia pregnant women / 中国医师杂志

ABSTRACT

Objective To detect the levels of serum fatty factor complement C1q tumor necrosis factor-related protein (CTRP) 3 and CTRP9 in pre-eclampsia (PE) pregnant women,and to analyze their correlations with the levels of glucose metabolism and lipid metabolism indexes.Methods From January 2016 to March 2018,96 pregnant women with mild pre-eclampsia and 90 pregnant women with severe preeclampsia were selected,another 100 healthy pregnant women were selected as control group.The levels of serum CTRP3 and CTRP9 were detected by enzyme linked immunosorbent assay (ELISA);the levels of triglyceride (TG),cholesterol (TC),low density lipoprotein cholesterol (LDL),high density lipoprotein cholesterol (HDL),free fatty acid (FFA),and fasting blood glucose (FPG) were measured by automatic biochemical analyzer;fasting insulin level (FINS) was measured by automatic chemiluminescence instrument.The insulin resistance index (HOMA-IR) was calculated and the differences among the three groups were compared.Pearson was used to analyze the correlation between the levels of CTRP3 and CTRP9 and the indexes of glycolipid metabolism.Results The serum CTRP3 and CTRP9 levels of PE patients in severe group and mild group were significantly lower than those in control group (P ＜ 0.05),and serum CTRP3 and CTRP9 levels in severe PE patients were significantly lower than those in mild PE patients (P ＜ 0.05);the serum lipid metabolism indexes levels of FFA,TG,TC,and LDL of PE patients in severe group and mild group were significantly higher than those in control group (P ＜ 0.05),and HDL level was significantly lower than that of the control group (P ＜ 0.05);the levels of serum lipid metabolism indexes FFA,TG,TC,and LDL of PE patients in severe group were significantly higher than those in mild group (P ＜ 0.05),and the level of HDL was significantly lower than that in mild group (P ＜ 0.05).The levels of serum glucose metabolism indexes FPG,FINS,and HOMA-IR of PE patients in severe group and mild group were significantly higher than those in control group (P ＜ 0.05);the levels of FPG,FINS,and HOMA-IR in severe PE patients were significantly higher than those in mild PE patients (P ＜ 0.05).Pearson test showed that serum CTRP3 and CTRP9 levels in PE patients were negatively correlated with FFA,TG,TC,FPG,FINS,and HOMA-IR levels (P ＜ 0.05),and positively correlated with HDL level (P ＜ 0.05).Conclusions The levels of serum CTRP3 and CTRP9 are decreased in PE patients,which is negatively correlated with FFA,TG,TC,FPG,FINS,and HOMA-IR levels,and positively correlated with HDL level.They may be indirectly involved in the pathogenesis and progression of PE by affecting the glycolipid metabolism in pregnant women.