The relationships between the expression of miR-30a-5p, miR-211 and prognosis in colorectal cancer / 中国医师杂志

ABSTRACT

Objective:To analyze the expression of miR-30a-5p and miR-211 in colorectal cancer tissues, and to explore the relationships between the expression of miR-30a-5p, miR-211 and the clinicopathological characteristics, prognosis of colorectal cancer.Methods:80 patients with colorectal cancer treated in our hospital from February 2013 to December 2015 were retrospectively analyzed, and colorectal cancer tissues and corresponding adjacent tissues (≥3 cm far from the lesion) were collected during operation. Real-time fluorescence quantitative analysis (qRT-PCR) was used to detect the expression levels of miR-30a-5p and miR-211 in tissues, and the relationships between the expressions of miR-30a-5p, miR-211 and the clinicopathological characteristics, prognosis of colorectal cancer patients were analyzed.Results:The expression levels of miR-30a-5p and miR-122 in colorectal cancer tissues were significantly lower than those in adjacent tissues ( P<0.05). The expression levels of miR-30a-5p and miR-211 were not related to gender, age and location of tumors ( P>0.05), but related to differentiation, size of tumors, degree of invasion, tumor node metastasis (TNM) stage and lymph node metastasis ( P<0.05). There was a positive correlation between the expressions of miR-30a-5p and miR-211 in colorectal cancer ( r=0.337, P<0.05). The 3-year survival rates of the low-expression groups of miR-30a-5p and miR-211 were significantly lower than those of the high-expression groups of miR-30a-5p and miR-211 (all P<0.05). Low differentiation, high TNM stage, lymph node metastasis, low expression of miR-30a-5p and low expression of miR-211 were independent risk factors for poor prognosis of colorectal cancer patients ( P<0.05). Conclusions:The expressions of miR-30a-5p and miR-211 are low in colorectal cancer tissues, both of them are related to the clinicopathological characteristics and prognosis of colorectal cancer, such as the degree of differentiation of tumors, lymph node metastasis and so on, which may play a common role in influencing the occurrence and development of colorectal cancer.