Etiology and serum inflammatory factors of mild gastroenteritis with benign convulsion in infants / 中国医师杂志

ABSTRACT

Objective:⑴ To understand the pathogen distribution of mild gastroenteritis with benign infantile convulsion (BICE). ⑵ To analyze the levels of serum interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), peripheral blood leukocyte count (WBC) and hemoglobin (Hb) in children with BICE, and to explore whether they are related to the convulsion of BICE.Methods:From May 2017 to May 2018, 30 BICE children in the Department of Pediatrics of Inner Mongolia Autonomous Region Maternal and Child Health Hospital were selected as the observation group, while 30 mild gastroenteritis children without convulsion attack were selected as the control group. The detection of enterovirus uses colloidal gold method or fluorescence polymerase chain reaction (PCR) method. Serum IL-6 and TNF-α were detected by chemiluminescence. The levels of serum inflammatory factors, WBC and Hb were compared between the control group and the observation group, as well as between the children with different seizure times and duration.Results:⑴ The onset of BICE group was mainly in autumn and winter. The incidence rate of control group in summer was higher than that in BICE group, with statistically significant difference ( P<0.05). ⑵ In BICE group, rotavirus, norovirus and Coxsackie virus were 46.67%, 6.67% and 10%, respectively. ⑶ The levels of serum [IL-6 (16.37±11.97)pg/ml] and [TNF-α (11.96±7.10)pg/ml] in BICE group were higher than those in control group [IL-6 (10.30±6.95)pg/ml, TNF-α (6.95±4.97)pg/ml], with statistically significant difference ( P=0.019, P=0.003). ⑷ The levels of serum [IL-6 (24.83±14.34)pg/ml] and [TNF-α (16.93±6.73)pg/ml] in children with convulsion ≥ 2 times were higher than those in children with convulsion < 2 times [IL-6 (11.48±6.91)pg/ml, TNF-α (9.07±5.66)pg/ml], with statistically significant difference ( P=0.013, P=0.002). The levels of serum [IL-6 (27.84±14.42)pg/ml] and [TNF-α (18.00±6.74)pg/ml] in children with convulsion duration ≥ 5 min were higher than those in children with convulsion duration <5 min [IL-6 (12.20±7.76)pg/ml, TNF-α (9.75±5.95)pg/ml], with statistically significant difference ( P=0.001, P=0.003). ⑸ Compared with the control group, there was no significant difference in WBC and Hb content of blood routine test in BICE group ( P>0.05). Conclusions:⑴ Rotavirus infection is the main pathogen of BICE in this region. ⑵ Children with BICE have a certain degree of immune regulation dysfunction. IL-6 and TNF-α may participate in the convulsion process of BICE. The higher the levels of serum IL-6 and TNF-α, the more severe the convulsion degree in children. ⑶ This study shows that WBC number and Hb content in blood routine have nothing to do with the occurrence of BICE.