Changes and clinical significance of serum ischemia-modified albumin in patients with coronary heart disease / 中国医师杂志

ABSTRACT

Objective:To observe the changes and clinical significance of serum ischemia-modified albumin (IMA) level in patients with coronary atherosclerotic heart disease (CHD).Methods:80 patients admitted in our hospital from January 2018 to January 2020 were selected as observation group, and 60 healthy controls were selected as control group. In the observation group, there were 14 patients with silent myocardial ischemia (SMI), 28 patients with angina pectoris(AP), 27 patients with myocardial infarction (AMI) and 11 patients with ischemic cardiomyopathy (ICM). According to the number of different pathological vessels in coronary angiography (CAG), the patients in the observation group were divided into single vessel group (38 cases), two vessels group (29 cases) and three vessels group (13 cases). The serum level of high-sensitivity cardiac troponin T (hs-cTnT), creatine kinase isoenzyme (CK-MB), high sensitivity C-reactive protein (hs-CRP)and IMA among groups was compared. Pearson method was used to analyze the correlation between IMA level and other indicators.Results:The levels of hs-cTnT, hs-CRP, CK-MB and IMA in the observation group were higher than those in the control group ( P<0.05). The levels of hs-cTnT, hs-CRP and IMA were significantly lower at 24 hours after treatment than those at admission; at 72 hours after treatment, the above indexes level was significantly lower ( P<0.05). The level of CK-MB increased 24 hours after treatment ( P<0.05), and decreased 72 hours after treatment ( P<0.05). The levels of hs-cTnT, hs-CRP, CK-MB and IMA in AP group, AMI group and ICM group were higher than those in SMI group ( P<0.05). The levels of CK-MB and IMA in AMI group were significantly higher than those in other groups ( P<0.05). The levels of hs-cTnT, hs-CRP, CK-MB and IMA were higher in the two vessels group and three vessels group than in the single vessel group ( P<0.05). The levels of CK-MB and IMA in the three vessels group were higher than those in the two vessels group ( P<0.05). The correlation analysis showed that serum IMA was positively correlated with hs-cTnT, hs-CRP and CK-MB ( r=0.554, 0.541, 0.521, P<0.05). Conclusions:The abnormal increase of serum IMA in CHD is closely related to myocardial cell injury and inflammatory response. The detection of serum IMA level is conducive to the early diagnosis and condition evaluation of CHD.