Effect of interleukin6 on the malignant progression of ovarian cancer / 中国综合临床

ABSTRACT

Modern oncology believes that tumor-associated inflammation is one of the prominent features of tumor microenvironment.The occurrence and development of ovarian cancer is inseparable from the influence of inflammatory factors in the microenvironment.Interleukin-6 (IL-6) is an important pro-inflammatory factor that regulates tumor cell growth.Current studies found that the expression of IL-6 and IL-6 receptor both increase in patients with ovarian cancer, which are closely related to poor clinical prognosis.The mechanism of effect of IL-6 on the malignant progression of ovarian cancer has been a research hotspots in the field of tumor microenvironment.In combination of the research results of this group in recent years, we mainly review the role of IL-6 in ovarian cancer including proliferation, invasion and metastasis, blood system disorders and drug resistance.Then, we introduce the research frontiers and application prospects of IL-6 targeted therapy for ovary cancer.