Role of tumor necrosis factor-like ligand 1 aberrance in the immune regulation of inflammatory bowel disease / 中国综合临床

ABSTRACT

Inflammatory bowel disease includesulcerative colitis and Crohn′s disease.At present, it is generally believed that the pathogenesis of inflammatory bowel disease is that environmental factors act on the genetic susceptible.With the participation of intestinal flora, it starts the intestinal immune response which is difficult to stop and alternates between attack and remission.However, the pathogenesis of IBD is not very clear, so it is important to further explore and clarify the pathogenesis of IBD for the search of new treatment.Tumor necrosis factor-like ligand 1 aberrance(TL1A) is a newly discovered new member of tumor necrosis factor family and a susceptible gene of inflammatory bowel disease.TL1A plays a key role in the regulation and connection between innate immunity and adaptive immunity of mucosal inflammation, and thus plays an important role in inflammatory bowel disease.This article reviews the role of TL1A in the immune regulatory mechanism of inflammatory bowel disease.