Analysis of the related factors of early abortion after long plan assisted pregnancy in mid luteal phase / 中国综合临床

ABSTRACT

Objective:To analyze the influencing factors of early miscarriage after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer treatment.Methods:From January 2015 to August 2018, 461 cases of pregnant women who received mid luteal phase ovulation induction in Beijing Obstetrics and Gynecology Hospital, Capital Medical University were retrospectively analyzed.According to the pregnancy outcome, the patients were divided into early miscarriage group (54 cases) and delivery group (407 cases). The general situation and ovulation induction outcome of the two groups were compared, and the related factors of early spontaneous miscarriage were analyzed.Results:There was no significant difference in age, pre pregnancy body mass index, type of infertility, history of abortion, thyrotropin, basal endocrine level, number of antral follicles, daily hormone level of hCG injection, and number of oocytes retrieved between early miscarriage group and delivery group (all P>0.05). Logistic regression analysis showed that age and basal follicle stimulating hormone were risk factors for early miscarriage.The risk of early miscarriage in patients with age ≥ 35 years old was 1.854 times higher than that in patients younger than 35 years old, 95% CI 1.027-3.347, P=0.041; the risk of early abortion in patients with basal FSH ≥ 10 U/L was 1.499 times higher than that in patients with basal FSH<10 U/L, 95% CI 0.776-2.895, P=0.048. Conclusion:Age and basal follicle stimulating hormone are risk factors for early miscarriage after long protocol assisted pregnancy in mid luteal phase.