Correlation analysis of serum IgE concentration of dermatophagoides pteronyssinus allergen components Ⅰ and acute attack of asthma in children / 中国综合临床

ABSTRACT

Objective:To explore the correlation of Dermatophagoides pteronyssinus allergen components Ⅰ (Der p1 IgE) level and acute attack of childhood asthma.Methods:Using a case-control study, 52 asthmatic children treated in Children′s Hospital of Xuzhou Medical University from June to October in 2018 and June to October in 2019 were selected as the asthmatic group.In the same period, 52 healthy children with gender and age matched with asthma group were selected as control group.In addition, according to the grading standard of severity of asthma in children aged over 6 years, the asthma group was divided into mild moderate group ( n=33) and severe critical group ( n=19). The serum concentrations of Der p1 IgE were detected by enzyme-linked immunosorbent assay.The serum concentrations of Der p1 IgE in the two groups were compared.Logistic regression analysis was used to analyze the correlation between serum Der p1 IgE concentration and acute attack of asthma in children. Results:The Der p1 IgE concentration in asthmatic group was (409.63±51.50)×10 3 IU/L, which was significantly increased compared to the healthy case-control group(314.44±8.75)×10 3 IU/L.The difference was statistically significant ( t′=13.139, P<0.01). The Der p1 IgE concentrations in mild-moderate group and severe-critical group were (385.81±14.75)×10 3 IU/L and (451.00±65.45)×10 3 IU/L, respectively.The difference was statistically significant ( t′=4.279, P<0.01). Logistic regression result showed that peripheral serum Der p1 IgE level had a correlation with acute attack of childhood asthma (regression coefficien t=1.322, OR=3.596, 95% CI 2.874-8.957, P=0.003). Conclusion:The level of serum Der p1 IgE in children with acute exacerbation of asthma was higher than that of healthy children, suggesting that serum Der p1 IgE may be involved in the acute attack process of childhood asthma.