Application value of deep learning ultrasound in the four-category classification of breast masses / 中华超声影像学杂志

ABSTRACT

Objective:To explore the application value of artificial intelligence-assisted diagnosis model based on convolutional neural network (CNN) in the differential diagnosis of benign and malignant breast masses.Methods:A total of 10 490 images of 2 098 patients with breast lumps (including 1 132 cases of benign tumor, 779 cases of malignant tumor, 32 cases of inflammation, 155 cases of adenosis) were collected from January 2016 to January 2018 in Beijing Tiantan Hospital Affiliated to the Capital University of Medical Sciences. They were divided into training set and test set and the auxiliary artificial intelligence diagnosis model was used for training and testing. Two sets of data training models were compared by two-dimensional imaging (2D) and two-dimensional and color Doppler flow imaging (2D-CDFI). The ROC curves of benign breast tumors, malignant tumors, inflammation and adenopathy were analyzed, and the area under the ROC curve (AUC) were calculated.Results:The accuracies of 2D-CDFI ultrasonic model for training group and testing group were significantly improved. ①For benign tumors, the result from training set with 2D image was sensitivity 92%, specificity 95%, AUC 0.93; the result from training set with 2D-CDFI images was sensitivity 93%, specificity 95%, AUC 0.93; the result for test set with 2D images was sensitivity 91%, specificity 96%, AUC 0.94; the result for test set with 2D-CDFI images was sensitivity 93%, specificity 94%, AUC 0.94. ② For malignancies, the result for training set with 2D images was sensitivity 93%, specificity 97%, AUC 0.94; the result for training set with 2D-CDFI images was sensitivity 93%, specificity 96%, AUC 0.94; the result for test set with 2D images was sensitivity 93%, specificity 96%, AUC 0.94; the result for test set with 2D-CDFI images was sensitivity 93%, specificity 96%, AUC 0.94. ③For inflammation, the result for training set with 2D images was sensitivity 81%, specificity 99%, AUC 0.91; the result for training set with 2D-CDFI images was sensitivity 86%, specificity 99%, AUC 0.89; the result for test set with 2D images was sensitivity 100%, specificity 98%, AUC 0.98; the result for test set with 2D-CDFI images was sensitivity 100%, specificity 99%, AUC 0.96. ④For adenopathy, the result for training set with 2D images was sensitivity 88%, specificity 97%, AUC 0.94; the result for training set with 2D-CDFI images was sensitivity 93%, specificity 98%, AUC 0.94; the result for test set with 2D images was sensitivity 94%, specificity 98%, AUC 0.93; the result for test set with 2D-CDFI images was sensitivity 88%, specificity 99%, AUC 0.90. Its diastolic accuracy was not affected even if the maximum diameter of the tumor was less than 1 cm.Conclusions:Through the deep learning of artificial intelligence based on CNN for breast masses, it can be more finely classified and the diagnosis rate can be improved. It has potential guiding value for the treatment of breast cancer patients.