The incidence and clinical characteristics of metabolic syndrome in rheumatoid arthritis and osteo-arthritis / 中华风湿病学杂志

ABSTRACT

Objective:To explore the difference between the prevalence of metabolic syndrome (MetS) and its influencing factors between rheumatoid arthritis (RA) patients and osteoarthritis (OA) patients.Methods:2 024 patients with RA were selected as the experimental group inthe First Central Hospital of Tianjin from January 1, 2014 to March 12, 2019. A total of 1 271 patients with OA who were treated at the same time served as the control group.Relevant indicators were measured, and correlation analysis was performed using logistic regression.Results:The prevalence of MetS in the past six years did not differ significantly inpatients with RA ( χ2=5.77, P=0.06) and OA ( χ2=1.11, P=0.57). MetS risk factors were more prevalent inpatients with OA, and the prevalence of MetS in patients with OA was also higher than patients with RA ( χ2=19.07, P<0.01). In logistic regression model, the prevalence of MetS was positively correlated with body weight {RA 1.14[(95% CI(1.10, 1.18), P<0.01]; OA 1.11[95% CI(1.07, 1.16), P<0.01]}, blood levels of triglyceride {RA2.64[95% CI(1.58, 4.40), P<0.01] and OA 2.91[95% CI(1.32, 6.43), P=0.01]}, and glucose {RA1.67[95% CI(1.42, 1.97), P<0.01] and OA 1.76[95% CI(1.31, 2.35), P<0.01]}, and negatively correlated with blood level of high-density lipoprotein cholesterol{RA 0.09[95% CI(0.02, 0.32), P<0.01] and OA 0.03[95% CI(0.01, 0.25), P<0.01]} in patients with RA and OA. MetS risk factors such as serum creatinine (Scr) only presented in RA patients 1.04 [ OR 95% CI(1.01, 1.06), P<0.01]. Conclusion:The prevalence of MetS did not decrease in patients with chronic inflammatory arthritis in the past six years, and OA patients havea greater risk of MetS.