Study on the feasibility of dose estimation by the dose-response curves based on different types of dicentrics / 中华放射医学与防护杂志

ABSTRACT

Objective:To investigate the feasibility of dose estimation based on the dose-response curves established by different types of dicentrics (dic).Methods:Human peripheral blood samples were irradiated by 60Co γ-rays at the doses of 0, 0.5, 1, 2, 3, 4, 5 and 6 Gy with the dose rate of 0.27 Gy/min, and chromosome preparation was carried out. The different types of dics were analyzed. The dose-response curves were fitted with software of Chromosomal Aberration Calculation Software (CABAS). Two samples were used to validate the dose-response curves. Results:The aberration rates of different types of dics increased with the exposure doses ( R2=0.886-0.943, P<0.01). The proportion of typical and single-ended dic components accounted for more than 92% of all types of dic, while the proportion of short-range dic and double-ended dic components was less than 4% at each dose point. The dose-response curves based on different types of dics were established ( R2=0.998, P<0.01). There was no significant difference in the doses estimated by four different dose-response curves ( P>0.05). The relative deviations between actual and predict doses were less than 13.08% by using dose-response curve based on typical dics. Conclusions:Dose-response curves based on different types of dics have the feasibility of dose estimation.