Relationship between T cell subsets in peripheral blood and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma / 中华放射肿瘤学杂志

ABSTRACT

Objective:To observe the relationship between peripheral blood T cell subsets and clinical characteristics and prognosis of Uygur women with advanced cervical squamous cell carcinoma in Xinjiang.Methods:A total of 185 patients pathologically diagnosed with stage Ⅱ B-IVA cervical squamous cell carcinoma admitted to Cancer Hospital Affiliated to Xinjiang Medical University from January 2015 to December 2018 were selected. The relationship between T cell subsets in peripheral venous blood and clinical characteristics and prognosis was analyzed. Results:CD 4+ T cells, CD 8+ T cells and CD 4+/CD 8+ T cell ratio were significantly correlated with clinical stage, tumor diameter and body mass index (BMI)(all P<0.05). The later Federation International Association of Gynecology and Obstetrics (FIGO) tumor stage, the larger the tumor diameter, the higher the BMI, and the higher the CD 8+ T cells and the lower the CD 4+ T cell and CD 4+/CD 8+ T cell ratio. The count of CD 4+ T cells was decreased in patients with lymph node metastasis. Cox’s univariate analysis showed that FIGO stage, age, lymph node metastasis, tumor diameter, BMI, CD 4+ T cells, CD 8+ T cells, CD 4+/CD 8+ T cell ratio and treatment methods were the important factors affecting the overall survival (OS). Multivariate analysis showed that BMI, treatment method, CD 4+ T cells and tumor diameter were the independent prognostic factors affecting OS (all P<0.05). Conclusions:The level of T cell subsets in peripheral blood of Uygur cervical cancer patients is out of balance. CD 4+ T cells, CD 8+ T cells and CD 4+/CD 8+ T cell ratio are associated with FIGO stage, tumor diameter and BMI, and CD 4+ T cells are correlated with lymph node metastasis. BMI, treatment method, tumor diameter and CD 4+ T cell are the independent prognostic factors affecting the OS of patients with cervical cancer.