A study on the relationship between cerebrovascular hemodynamics, related physiological, and biochemical indexes and cerebral ischemia / 中华健康管理学杂志

ABSTRACT

Objective:This study aimed to analyze the relationship between cerebral ischemia and cerebral blood flow dynamics (cerebrovascular function score), related physiological, and biochemical indexes.Methods:We selected 366 patients who underwent regular physical examination, cerebrovascular hemodynamics test, and head MRI in the health management center of Shandong Electric Power Central Hospital from May 2016 to April 2019. The patients with cerebral ischemia were selected as the case group (264 cases), and those without cerebral ischemia as the control group (102 cases) to analyze the differences in cerebrovascular function scores, blood pressure, body mass index, and related biochemical indexes between the two groups. The risk factors were also analyzed by multiple logistic regression analysis.Results:The average age of cerebral the ischemia group was (53.0±7.6) years, which consisted of 211 men and 53 women. The average age of the control group was (48.7±7.3) years, which consisted of 87 men and 15 women. The comparison of the mean of continuous variables between the two groups of subjects shows that the mean age [(53.0±7.6) years old vs. (48.7±7.3) years old] and systolic blood pressure [(127.70±17.06) mmHg vs.(122.36±14.75) mmHg] (1 mmHg=0.133 kPa) of cerebral ischemia group were significantly higher than that of control group. The high-density lipoprotein level [(1.29±0.26) mmol/L vs. (1.37±0.30) mmol/L] and cerebrovascular function score [(86.55±18.41) vs. （92.16±10.77）] were significantly lower than those in the control group. The exposure rate of systolic blood pressure ≥140 mmHg and cerebrovascular function score <75 [16.7%(44 cases) vs. 2.9%(3 cases)] in the ischemic group was significantly higher than that in the control group, with statistically significant differences ( P<0.05). Multivariate logistic regression results showed that the variables included in the regression equation of the numeration data model were age and cerebrovascular function score, and the OR (95% CI) were 1.062 (1.020-1.105） and 6.838 (1.583-29.547). Conclusion:Aging, low high-density lipoprotein cholesterol level, and low cerebrovascular function score may be the risk factors affecting MRI-defined cerebral ischemia.