The correlation between serum uric acid levels and predisposing risk factors for coronary heart disease in elderly patients / 中华老年医学杂志

ABSTRACT

Objective:To examine potential predisposing risk factors for coronary heart disease(CHD)in elderly patients and the correlation between serum uric acid levels and the predisposing risk factors in elderly patients with CHD.Methods:Clinical data of 200 elderly inpatients with CHD(CHD group)and 150 elderly outpatients without CHD(control group)at our hospital from January 2017 to January 2019 were retrospectively analyzed.Peripheral venous blood was collected from patients immediately after admission, and serum uric acid levels were measured.Baseline information of patients was recorded.Potential predisposing risk factors of CHD were identified by single-factor and multiple-factor analysis, and serum uric acid levels were compared against predisposing risk factors.The correlation between serum uric acid levels and predisposing risk factors in elderly patients with CHD was analyzed.Results:According to preliminary single-factor analysis, smoking, diabetes mellitus, low high-density lipoprotein cholesterol(HDL-C)hypolipidemia, family history of CHD and glomerular filtration rate seemed to be predisposing risk factors for elderly patients with CHD( χ2=6.739, 15.655, 6.331, 9.615, 23.279, P<0.05). Multiple-factor analysis showed that smoking, diabetes mellitus, low HDL-C hypolipidemia, family history of CHD and glomerular filtration rate were predisposing risk factors for elderly patients with CHD( OR=1.777, 2.381, 1.883, 1.967, 3.205, all P<0.05). Serum uric acid levels in elderly CHD patients with smoking, diabetes mellitus, low HDL-C hypolipidemia, family history of CHD or glomerular filtration rate<100 ml/min were higher than in patients without any of those conditions, and the difference was statistically significant( t=8.017, 5.907, 8.509, 7.164, 13.839, P<0.001). Spearman correlation analysis showed that serum uric acid levels were positively correlated with risk factors such as smoking, diabetes mellitus, and family history of CHD in elderly patients with CHD( r=0.409, 0.422, 0.422, all P<0.001), and were negatively correlated with low HDL-C hypolipidemia and glomerular filtration rate( r=-0.428 and -0.481, all P<0.001). Conclusions:High level serum uric acid is closely related to many CHD risk factors such as smoking and diabetes mellitus and may be an independent risk factor for the onset of CHD.