Correlation between apolipoprotein E gene polymorphism and lipid metabolism in elderly patients with cardiovascular and cerebrovascular diseases / 中华老年医学杂志

ABSTRACT

Objective:To investigate the association of apolipoprotein E(ApoE)gene polymorphism with lipid metabolism and common chronic cardiovascular and cerebrovascular diseases in the elderly.Methods:A total of 4 322 elderly outpatients and inpatients from our hospital were enrolled in this retrospective analysis.The distribution of ApoE subtypes in the elderly was analyzed.Then 600 cases(321 cases with atherosclerosis and 279 healthy controls)were included to analyze blood lipid-related biochemical indexes.ApoE genotypes were determined by DNA microarray analysis.Results:ApoE E3 was the most common subtype, making up 67.1%(2 898/4 322)in this study population.The distribution of ApoE subtypes in the elderly with chronic cardiovascular and cerebrovascular diseases was basically the same as that in the elderly population.However, in patients with neurodegenerative diseases, the rate of ApoE E4 carriers was 26.4%(152/576), which was higher than that of ApoE E2 carriers(12.2%, 70/576)( P<0.01). Triglyceride(TG)levels in those with atherosclerosis carrying ApoEε2 and ε4 alleles were higher than those in healthy controls carrying ApoEε2 and ε4 alleles ApoEε2 alleles (1.85±2.09)mmol/L vs.(2.00±1.44)mmol/L, ApoEε4 alleles (1.53±1.31)mmol/L vs.(1.84±1.32)mmol/L, P<0.05.TG( OR=4.360, 95% CI 2.150-8.844), high density lipoprotein cholesterol( OR=0.486, 95% CI 0.307-0.770), low density lipoprotein cholesterol( OR=2.321, 95% CI 1.020-5.281)and ApoE alleles( OR=0.335, 95% CI 0.210-0.533)were risk factors for atherosclerosis( P<0.01). Conclusions:ApoE polymorphism is associated with lipid metabolism in elderly patients.Genetic background may be among the factors affecting lipid metabolism.ApoE ε4 allele carriers have an increased risk of dyslipidemia, cardiovascular and neurodegenerative diseases.