Infection-related factors and inflammatory mechanisms in Alzheimer's Disease / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12): 1342-1345, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-869569
ABSTRACT
Alzheimer's disease(AD), characterized by a progressive decline in cognitive functions, may manifest differently in disease progression.Many researchers have turned their attention to the role of microbes in AD pathogenesis, with increasing evidence suggesting that microbial infections in the central nervous system and peripheral tissues may trigger the innate immune system via direct and/or indirect inflammatory reaction of the nervous system, then leading to the accumulation of amyloid-β(Aβ)plaques and hyperphosphorylated tau in the brain in AD.This article reviews the pathogenesis of AD concerning inflammatory reaction caused by microbes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Geriatrics
Year:
2020
Type:
Article
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