Application and research progress of liquid biopsy in renal cell carcinoma / 中华泌尿外科杂志

ABSTRACT

Liquid biopsy is a noninvasive analysis of tumor related substances in fluid samples, which overcomes the limitations of traditional histological biopsy, and beneficial for early diagnosis and differentiation, prediction of response to treatment, longitudinal monitoring of disease progression and prediction of prognosis. Renal cell carcinoma is lack of mature serum tumor markers, and the diagnosis and monitoring of the disease still rely on imaging. In recent years, liquid biopsy has become a hotspot in renal cell carcinoma. In this paper, we will review the application and research progress of circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating tumor RNA (ctRNA), exosomes, tumor "education" platelets (TEPs) in renal cell carcinoma.