Association between thyroid hormones and visceral fat area in the patients with type 2 diabetes / 中华内分泌代谢杂志

ABSTRACT

Objective:To explore the association between thyroid hormones and visceral fat area(VFA) in the patients with type 2 diabetes.Methods:A total of 729 patients with type 2 diabetes, who joined National Metabolic Management Center(MMC) through Ningbo First Hospital from March, 2018 to July, 2019, were enrolled in this study. Blood tests were taken to assess their thyroid hormones and biochemical indexes. VFA and subcutaneous fat area(SFA) were obtained through bioelectrical impedance analysis. Statistics were later analyzed by Spearman correlation analysis and multivariate linear regression. Results:Spearman correlation analysis showed that VFA were positively correlated with T 3、FT 3( r=0.225 and 0.211, P<0.01), and VFA were inversely correlated with FT 4( r=-0.112, P<0.01). No correlation was found between VFA and either of T 4 or TSH( P>0.05). Multivariate linear regression analysis indicated that VFA was independently correlated with FT 4 and FT 3( P<0.01). An increment of 1 pmol/L in FT 4 was associated with 1.759 cm 2 increase in VFA, and increment of 1 pmol/L in FT 3 was associated with 3.256 cm 2 decrease in VFA. Conclusion:VFA in patients with type 2 diabetes are correlated with FT 3 and FT 4.