Enlightenment of ferroptosis study on the occurrence and development of clinical diseases / 中华内分泌代谢杂志

ABSTRACT

Ferroptosis is a new concept of cell death. With the deepening of ferroptosis research, there have been many new understandings of the correlation of ferroptosis with clinical outcomes, diagnosis, and treatment of diseases. Ferroptosis is different from programmed cell death such as apoptosis and autophagy. Ferroptosis is an iron-dependent adjustable cell death that is regulated by glutathione peroxidase 4(GPX4), which requires iron to participate. Moreover, ferroptosis is involved in in many disease processes such as tumors and neurodegeneration. In 2019, journals such as Nature and Cell successively published studies on the mechanism of ferroptosis and clinical diseases, and " ferroptosis" has been increasingly recognized by clinical researchers. Therefore, understanding the main characteristics and regulation mechanism of ferroptosis as well as the influence pathway and mode of iron metabolism process on the occurrence of ferroptosis in vivo is very beneficial to understand the correlation between clinical diseases and ferroptosis, and to enlighten and expand the thinking of clinical diagnosis and treatment. This article reviewed the literature on ferroptosis as well as the relationship between ferroptosis and clinical diseases, in order to gain a deeper understanding of the new concept of ferroptosis.