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Meta-analysis of randomized controlled trials for the association of incretins with fractures risk in patients with type 2 diabetes / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism ; (12): 844-854, 2020.
Article in Chinese | WPRIM | ID: wpr-870109
ABSTRACT

Objective:

To conduct a meta-analysis of clinical data to investigate the relationship between incretins and fracture in order to provide individualized hypoglycemic agents for type 2 diabetic patients with osteoporosis.

Methods:

PubMed, Embase, Web of Science, and Cochrane databases were searched up to January 1, 2018 for randomized controlled trials(RCTs)and the relationship between incretins and fracture was explored by meta-analysis.

Results:

The meta-analysis showed that the use of incretin was not associated with fracture risk compared with placebo or other positive hypoglycemic agents( OR 0.972, 95% CI 0.876-1.079). But in the subgroup analysis, 100 mg/d sitagliptin( OR 0.495, 95% CI 0.304-0.806)or 1.8 mg/d liraglutide( OR 0.621, 95% CI 0.413-0.933)reduced fracture risk.

Conclusions:

Meta-analysis shows no increase in the incidence of fracture events after the use of incretin. 100 mg/d sitagliptin or 1.8 mg/d liraglutide may exert protective effects on bone metabolism. However, the included data are from the reports of fracture adverse reactions in RCT studies, and large-scale clinical studies are needed to confirm these findings.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Etiology study / Systematic reviews Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Etiology study / Systematic reviews Language: Chinese Journal: Chinese Journal of Endocrinology and Metabolism Year: 2020 Type: Article