Research progress on risk factors of tophus formation / 中华全科医师杂志

ABSTRACT

Tophus is the sign of chronic gout, which can lead to bone destruction, joint dysfunction, and significantly increase the risk of cardiovascular disease and death. Tophus has a structure of chronic foreign body granuloma,and extracellular reticular trap of neutrophils may be the main mechanism for the formation of tophi. Several factors can lead to the tophus formation. This article reviews the recent advances in the study of biology,risk factors and therapy of tophus.