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Risk factors of sarcopenia in patients receiving maintenance peritoneal dialysis / 中华全科医师杂志
Chinese Journal of General Practitioners ; (6): 913-917, 2020.
Article in Chinese | WPRIM | ID: wpr-870730
ABSTRACT

Objectives:

To investigate the risk factors of sarcopenia in patients receiving maintenance peritoneal dialysis (MPD).

Methods:

One hundred and thirteen patients receiving maintenance MPD for ≥3 months during January and December 2017 were enrolled in this study. According to the Asian Working Group for Sarcopenia(AWGS)algorithm, there were 26 patients with sarcopenia accounting for 23.0% of all MPD patients. Demographic and anthropometric data were collected; laboratory tests were conducted, Kt/V urea and normalized protein equivalent of total nitrogen appearance were calculated; the bioelectrical impedance analysis (BIA) was performed and grip strength was tested. The nutritional status was evaluated with Subjective Global Assessment (SGA). Logistic regression was used to analyze the risk factors of sarcopenia in MPD patients.

Results:

BMI and dialysis dose of patients with sarcopenia were significantly lower than those without sarcopenia [(20.35±2.35) kg/m 2vs. (23.81±3.14) kg/m 2, t=-5.181, P<0.01; (5.57±1.83) L/d vs. (6.66±1.71) L/d, t=-2.795, P<0.01]. The bioelectrical impedance analysis showed that the total water content of patients with sarcopenia was higher than that of patients without sarcopenia [(35.44±6.40) kg vs. (28.52±4.89) kg, t=5.077, P<0.01]; while the protein content[(7.46±1.31) kg vs. (9.24±1.63) kg, t=-5.080, P<0.01] and skeletal muscle content [(20.54±4.18) kg vs. (25.88±4.95) kg, t=-4.980, P<0.01] of patients with sarcopenia were lower than those without sarcopenia. Multivariate analysis showed that decreased BMI( OR=0.934, 95 %CI 0.723-0.998, P<0.01) and body protein ( OR=0.927, 95 %CI 0.698-0.996, P<0.01), increased total body water( OR=1.382, 95 %CI 1.053-1.813, P=0.02) were independent risk factors for sarcopenia in MPD patients.

Conclusion:

The incidence of sarcopenia in MPD patients is high, which is associated with the excessive volume load and malnutrition of patients.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Risk factors Language: Chinese Journal: Chinese Journal of General Practitioners Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Etiology study / Risk factors Language: Chinese Journal: Chinese Journal of General Practitioners Year: 2020 Type: Article