The role of organophosphorus compounds in the pathogenesis of Alzheimer′s disease / 中华神经科杂志
Chinese Journal of Neurology
;
(12): 381-384, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-870811
ABSTRACT
Alzheimer′s disease is the most common neurodegenerative disease, which is characterized by the formation of neurofibrillary tangles and amyloid plaques in the brain, and the progressive loss of neurons. Epidemiological studies found that exposure to organophosphorus compounds increases the incidence of Alzheimer′s disease. Organophosphorus compounds accelerate the onset of Alzheimer′s disease pathology by inhibiting enzyme activity, promoting oxidative stress, and affecting axonal transport and nerve growth factor pathway. As a result, they cause cognitive dysfunction. Here we reviewed the current knowledge on the role of organophosphorus compounds in the pathogenesis of Alzheimer′s disease, in order to enhance our understanding of the environmental risk factors that contribute to the pathogenesis of Alzheimer′s disease, and to search for potential therapeutic targets for this disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
Language:
Chinese
Journal:
Chinese Journal of Neurology
Year:
2020
Type:
Article
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