Pay attention to cognitive impairment in Parkinson′s disease / 中华神经科杂志

ABSTRACT

Cognitive impairment is one of the most common non-motor symptoms of Parkinson′s disease, which is mainly related to abnormal protein deposition in related brain regions, impaired synaptic function, various transmitter system disorders and neuroimmune abnormalities. The incidence of Parkinson′s disease is relatively high, which seriously affects the quality of life of patients and imposes a heavy burden on society and families. At present, there are some early diagnostic markers in cerebrospinal fluid, peripheral fluid, gene and neuroimaging, which can be used for early warning and early recognition of cognitive impairment in Parkinson′s disease. Early warning and early diagnosis of cognitive impairment in Parkinson′s disease should be emphasized, and certain intervention and treatment can be carried out if necessary. Meanwhile, prospective, multicenter and large-sample high-quality clinical studies on cognitive impairment in Parkinson′s disease are needed urgently.