Research progress in epigenetic studies of focal cortical dysplasia / 中华神经科杂志

ABSTRACT

Belonging to the mlformations of cortical development category, focal cortical dysplasia (FCD) is a kind of desease caused by abnormal proliferation or abnormal migration of neurons in early embryo development. Epigenetics refers to changes in gene expression without changes in the nucleotide sequence of a gene, and these changes are heritable. It regulates gene expression mainly through DNA methylation, histone modification, chromatin remodeling and non-coding RNA.It is now considered that the epigenetic mechanism may be closely related to the pathogenesis of FCD, which has become a hotspot of FCD research.This paper will review the advances in epigenetic studies of FCD.