Research progress of update on inflammation and hemorrhagic transformation / 中华神经科杂志

ABSTRACT

Acute ischemic stroke is the most common type of stroke. Hemorrhagic transformation is one of the serious complications of acute ischemic stroke, which can aggravate the deterioration of neural system function and adverse prognosis. Several studies have shown that the occurrence of hemorrhagic transformation after acute ischemic stroke is associated with risk factors such as old age, massive infarction, diabetes mellitus and cardiogenic embolism. In recent years, many studies have confirmed that there is a significant correlation between inflammation and hemorrhagic transformation in acute ischemic stroke. Inflammatory cells were activated and aggregated in the blood vessel and brain parenchyma of acute ischemia-reperfusion injury, which released many inflammatory factors, caused the destruction of blood-brain barrier and hemorrhagic transformation. This review aims to explore the role of inflammation in the risk of hemorrhagic transformation and clinical prognosis in acute ischemic stroke.