Advance in Parkinson′s disease with restless legs syndrome / 中华神经科杂志

ABSTRACT

Restless legs syndrome is one of the common non-motor symptoms of Parkinson′s disease. Previous studies on Parkinson′s disease with comorbid restless legs syndrome generated mixed results. This article reviews the studies on Parkinson′s disease with restless legs syndrome on aspects of its pathophysiology, epidemiology, clinical symptoms, genetics and biomarkers, radiology and treatment, aiming to provide physicians a comprehensive understanding on the characteristics of two entities.