Research progress in NLRC4 inflammasome and related diseases / 中华微生物学和免疫学杂志

ABSTRACT

Inflammasomes are a group of multiprotein complexes in cells that could be activated when they perceive external microbial invasions and intrinsic aseptic stress signals. However, the activation of inflammasomes and the association between their structures and functions have not been elucidated. New progress has been made in the study of the structure and activation mechanism of NLRC4 inflammasome, which helps to fill the gaps. NLRC4 inflammasome plays an important role in systemic inflammation and programmed cell death, which provides important clues for the study of NLRC4-related inflammatory diseases including metabolic diseases, tumors and autoimmune diseases.