YAP/TAZ is related to the postoperative in-hospital death of Stanford type A aortic dissection / 中华胸心血管外科杂志

ABSTRACT

Objective:This study investigated the association between Yes-associated protein and WW domain-containing transcription regulator protein 1(YAP/TAZ) and the in-hospital surgical mortality rate of STAAD patients.Methods:The mouse β-aminopropionitrile monofumarate(BAPN) model was used to test the level of YAP/TAZ. From July 2016 to December 2016, the blood samples of 139 people who received routine physical examinations consecutively Beijing Anzhen Hospital were included as the control group.According to the inclusion and exclusion requiement, 95 consecutive patients with STAAD who underwent surgery in Beijing Anzhen Hospital during the same period, were involved in the final cohort study. The main outcome measure was in-hospital death. Their blood samples were regarded as the test group. The predictors of postoperative in-hospital death were confirmed by univariate regression analysis. Multivariable logistic regressions were used to analyze the association of the preoperative plasma level of TAZ and the postoperative in-hospital mortality of STAAD patients.Results:The YAP level showed less change in blood samples of both STAAD patients and the BAPN-induced STAAD mice compared to that of the sham control, while TAZ concentration experienced a significant increase. In the crude model, TAZ showed a positive correlation with in-hospital death( OR=1.327, 95% CI 1.014-1.737, P=0.0392). In adjusted model Ⅰ and adjusted modelⅡ, similar results were found( OR=1.348, 95% CI 1.010-1.803, P=0.0429; OR=1.353, 95% CI 1.008-1.816, P=0.0442). Conclusion:The high level of TAZ in the blood suggested poor surgical prognosis for STAAD patients, and patients with a TAZ level ≥13 ng/ml had much higher mortality.