Advances in the molecular mechanism of myocardial insulin resistance / 中华胸心血管外科杂志

ABSTRACT

Myocardial ischamic-reperfusion(MIRI) is one of the leading causes of cardiac dysfunction and even death with patient after cardiopulmonary bypass, its mechanism is complex and involved widely. Recent research has found that myocardial insulin resistance is an important mechanism of MIRI. But its mechanism has not been fully elucidated. Therefore, this paper reviews the study of myocardial insulin resistance and myocardial ischemia-reperfusion injury mechanism in recent years, to preliminarily clarify the regulatory role of insulin signal in MIRI and provide new ideas for the future research on the prevention and treatment of MIRI.