Current status and prospects of clinical management of circumferential tracheal transplantation / 中华胸心血管外科杂志

ABSTRACT

Large or complete defect of trachea is a difficult problem in surgical reconstruction. Tracheal replacement therapy is an effective treatment. Due to the lack of ideal graft materials and poor survival after transplantation, tracheal clinical transplantation still faces enormous challenges. Systematic review clinical translation of circumferential tracheal substitutes. Four primary methodologies have emerged tracheal allotransplantation, autologous tissue reconstruction, bioprosthetic reconstruction, and tissue engineered reconstruction. The main reason for the failure of current clinical graft are focused on that the lacks the mechanical properties of maintaining lumen patency, poor revascularization, and insufficient regeneration of epithelial cells and chondrocytes. The results show that laboratory work and animal experimental research on revascularization, re-epithelialization and further improvement of the mechanical properties of grafts are particularly important in order to promote the safer, more effective and widely used tissue engineering trachea for clinical diseases.