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Advances in the mechanism of photoreceptor cell death induced by inflammation in age-related macular degeneration / 中华眼底病杂志
Chinese Journal of Ocular Fundus Diseases ; (6): 825-828, 2020.
Article in Chinese | WPRIM | ID: wpr-871831
ABSTRACT
Photoreceptor cells are special retinal neurons with photo-transformation ability. Loss of photoreceptors in age-related macular degeneration (AMD) is secondary to RPE loss, leakage of serum components from the neovascularization and scar formation, which is one of the main mechanisms of irreversible visual impairment in patients with AMD. Many studies have shown that inflammatory environment is involved in the process of photoreceptor cell death. Aging, photooxidation injury and other factors affects the retinal microenvironment through different levels of mechanisms such as retinal pigment epithelial cells, retinal glial cells, hematogenous macrophages and inflammatory factors, which results in photoreceptor injuries and participates in the progression of AMD by drusen formation and neovascularization. This study reviews the research status and progress of inflammation and photoreceptor cell death, and provides new ideas for exploring the blinding mechanism and treatment strategies of AMD.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Ocular Fundus Diseases Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Ocular Fundus Diseases Year: 2020 Type: Article