Evaluation of interference factors in creatinine measurement by using new guideline CLSI EP7-A3 / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 307-311, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-871891
ABSTRACT
Objective:
To investigate the interfering factors in the determination of creatinine(Cr) using the American Clinical Laboratory Standards Association (CLSI) EP7-A3 document.Methods:
According to the CLSI EP7-A3 document, fresh serum (no hemolysis, lipemia, and jaundice) was used on the day of the experiment and confirmed the interfering substances through the pairing difference experiment and the point-to-point analysis method was used in the dose effect experiment to clarify the difference of interfering substances.Results:
Triglyceride (16.94 mmol/L), dobutamine hydrochloride (4.01 μmol/L), ascorbic acid (298 μmol/L) did not interfere with the determination of Cr. Free bilirubin (684 μmol/L), conjugated bilirubin (684 μmol/L), calcium hydroxybenzene sulfonate (144 μmol/L) and hemoglobin (10 g/L) were used as the maximum concentrations of interferences for the dose effect test, the results showed that the above interferences had negative interference on the determination of Cr.Conclusion:
According to EP7-A3, it is valuable to evaluate the interference factors of creatinine determination.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Evaluation studies
/
Practice guideline
Language:
Chinese
Journal:
Chinese Journal of Laboratory Medicine
Year:
2020
Type:
Article
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