Research progress in the measurement of glomerular filtration rate / 中华检验医学杂志

ABSTRACT

The glomerular filtration rate, which reflects the filtration function of kidney, is defined as the amount of plasma filtered from the kidney per unit of time. It cannot be measured directly, but only indirectly by the clearance rate of substances with specific properties. At present, the estimated GFR based on creatinine and(or) cystatin C has been gradually popularized, and its estimated formulas are all mathematical fitting formulas based on measured GFR. Different estimated formulas refer to different GFR measurement methods, which may lead to differences in GFR estimation. In this paper, several factors of GFR measurement by the clearance rate of substances, including material characteristics, clearance types, blood collection times and time points of plasma clearance, and comparison of different GFR measurement methods, are reviewed, and the new GFR measurement materials are briefly introduced. The plasma clearance of iohexol has a good application prospect because of its operability, easy standardization and promotion. Metabolomics has the potential to discover new markers for the measurement of GFR.