Research progress of small nucleolar RNAs in malignancy / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
;
(12): 1050-1054, 2020.
Article
in Chinese
| WPRIM
| ID: wpr-871998
ABSTRACT
Small nucleolar RNAs(snoRNAs) constitute a large group of non-coding RNAs. Canonical snoRNAs contain C/D box and H/ACA box types, with the length of 60-300 nucleotides. They are predominantly engaged in 2′-O-methylation or pseudouridylation of ribosomal RNAs. Mounting evidence supported that snoRNAs were a kind of detectable modulators affecting multiple cell behavior and eventually triggered tumorigenesis. The aberration of snoRNAs could regulate cancer-related signal pathways, expedite degradation of p53 protein and induce self-renewal. Herein, the snoRNAs′ structure and the latest progress of snoRNAs research in malignancy were briefly summarized, hoping to provide a new idea for the discovery of effective therapeutic targets and promising tumor prognosis markers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Laboratory Medicine
Year:
2020
Type:
Article
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