Effect of pores of silicone nasal implant on morphology of surrounding capsule / 中华医学美学美容杂志

ABSTRACT

Objective:To observe the morphologic changes of the tissue growing into the prefabricated pores on the surface of the silicone nasal implant.Methods:The silicone nasal implant with regularly arranged holes was cut into 1 cm-long segments and inserted to the forehead subperiosteal pockets of five female New Zealand white rabbits (1-year old) in the Animal Experiment Center of Dalian University. Three months later, the implant and its surrounding tissues were removed and observed after HE staining, β-catenin and vimentin immunohistochemical staining.Results:The capsule and its implant were visible to the naked eyes. The capsule was thin, and the white implant was seen through the capsule. The small pore of the implant showed darker color, indicating that the tissue here was thicker. The capsule was cut open and the capsule was torn off the implant. It could obviously be felt the resistance of the tissue in the small pores to the external pulling. Regular protrusions were found on the inner surface of the peeled capsule. No infection occurred in the surgery sites. Under the HE staining microscope, it was found that 100% pores in all the experimental samples were filled with the tissue. The thin capsule was formed around the implant. The capsule was continuously intact in and between the pores. No macrophages were seen. Some of the intracapsular tissues contained more fibers, and some were loose connective tissue. The immunohistochemical staining of β-catenin and vimentin showed that the tissue in the capsule was negative. Vimentin staining for the cytoplasmic scattered cells in the deep capsule tissue was positive.Conclusions:Based on the results of the experiments, it is concluded that the tissue can grow into the small pores of the implant. The capsules around the implant, which are smooth with protrusions, are connected on the surface of the implant and at the bottom of the pores. The protrusion pointing to the pores of implant is normal tissue covered by thin capsule.