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Correlation of matrix metalloproteinase 2 protein expression and microvessel density in gastric cancer tissues with clinicopathological characteristics of patients / 肿瘤研究与临床
Cancer Research and Clinic ; (6): 400-404, 2020.
Article in Chinese | WPRIM | ID: wpr-872517
ABSTRACT

Objective:

To explore the relationship of matrix metalloproteinase 2 (MMP-2) protein expression and microvessel density (MVD) in gastric cancer tissues with clinicopathological characteristics of patients as well as the significances.

Methods:

The disease-free survival (DFS) time, overall survival (OS) time and other clinicopathological data of 60 patients with gastric cancer after radical resection at Pei Country People's Hospital of Xuzhou from January 2010 to December 2015 were retrospectively analyzed. The MMP-2 protein expression and MVD marked by CD105 in 60 specimens of gastric cancer tissues and corresponding adjacent normal tissues were detected by using immunohistochemistry. The correlation of MMP-2 protein expression with MVD and their relationship with clinicopathological characteristics were analyzed.

Results:

The positive expression rate of MMP-2 protein in gastric cancer tissues was higher than that in adjacent normal tissues, and the difference was statistically significant [75% (45/60) vs. 17% (10/60), χ2 = 59.668, P < 0.05]. The MVD in gastric cancer tissues was higher than that in adjacent normal tissues, and the difference was statistically significant [32±5 vs. 20±4, t = -2.32, P < 0.05]. The expression of MMP-2 protein in gastric cancer tissues had no relationship with gender, age, the longest tumor diameter, tumor location, OS time, and DFS time (all P < 0.05), while the expression of MMP-2 protein in gastric cancer tissues had statistically significant relationship with the depth of tumor invasion, lymph node metastasis, TNM stage, and histological differentiation (all P < 0.05). There were no statistically significant differences in the expressions of MVD marked by CD105 in gastric cancer tissues of patients with different gender, age and tumor location (all P < 0.05). The expressions of MVD marked by CD105 in gastric cancer tissues had statistical differences in patients with different the longest tumor diameter, depth of tumor invasion, lymph node metastasis, TNM stage, histological differentiation, OS time, and DFS time (all P < 0.05). In gastric cancer tissues, the expression of MMP-2 protein and MVD were positively correlated ( r = 0.198, P = 0.027).

Conclusions:

The MMP-2 protein expression and MVD in gastric cancer tissues are on the increase, and play key roles in the occurrence and development of gastric cancer. They might cooperatively participate in the malignant progression of gastric cancer, and can be used as poor prognostic factors of gastric cancer.
Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Cancer Research and Clinic Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Prognostic study Language: Chinese Journal: Cancer Research and Clinic Year: 2020 Type: Article