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Effect of Xintong Oral Liquid in Improving Cardiac Function of Patients with Heart Failure and Syndrome of Qi Deficiency and Phlegm and Blood Stasis Caused by Acute Myocardial Infarction / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 128-133, 2020.
Article in Chinese | WPRIM | ID: wpr-872660
ABSTRACT

Objective:

To discuss the clinical efficacy of Xintong oral liquid on heart failure with syndrome of Qi deficiency, phlegm and blood stasis caused by acute myocardial infarction (AMI) and the effect on inflammatory factors.

Method:

One hundred patients were randomly divided into observation group (50 cases) and control group (50 cases) by random number table. Both groups got comprehensive treatment of western medicine. Patients in control group got simulated medicine of Xintong oral liquid, 20 mL/time, 3 times/day. Patients in observation group got Xintong oral liquid, 20 mL/time, 3 times/day. The treatment lasted for 4 weeks. Before the treatment, and at the second week and forth week after treatment, levels of cardiac troponin I (cTnI), cardiac troponin T (cTnT), heart type fatty acid binding proteinH-FABP), left ventricular ejection fraction (LVEF), cardiac output (CO), cardiac output per stroke (SV) and left ventricular end diastolic diameter (LVEDd), N-terminal B-type natriuretic peptide (NT-proBNP), lipoprotein phospholipase A2Lp-PLA2), high sensitive C-reactive proteinhs-CRP), interleukin-6IL-6) and tumor necrosis factor-α (TNF-α) were detected. The 6-minute walking test was performed to record the 6-minute walking distance and the ratio of 6 min walking distance to estimated value. Scores of traditional Chinese medicine (TCM) syndromesminnesota Heart Failure quality of life questionnaire (MLHFQ) and Killip classification of cardiac function were recorded. During the 2 months' follow-up, adverse cardiovascular events (MACE) were recorded, and the safety was evaluated.

Result:

At the second and fourth week, levels of cTnI, cTnT, H-FABP, NT-proBNP, Lp-PLA2hs-CRPIL-6 and TNF-α were lower than those in control group (P<0.01), and levels of LVEF, CO and SV were higher than those in control group (P<0.05, P<0.01). NT-proBNP was lower than control group (P<0.01). The 6-minute walking distance and the ratio of 6-minute walking distance to estimated value were all more than those in control group (P<0.01). Scores of TCM syndrome integral, MLHFQ, Killip heart function grading were lower than those in control group (P<0.05, P<0.01). Cumulative incidence of MACE was 12.0% (6/50), which was lower than 28.0% (14/50) in control group (χ2=4.251, P<0.05). Levels of Lp-PLA2hs-CRPIL-6 and TNF-α in observation group were lower those in control group (P<0.01).And there was no adverse reactions related to Xintong oral liquid.

Conclusion:

Based on the comprehensive treatment of Western medicine, Xintong oral liquid can reduce the degree of myocardial injury, protect myocardium, improve cardiac function, reduce inflammatory reaction, reduce the occurrence of mace, effectively control clinical symptoms, and improve exercise tolerance and quality of life.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2020 Type: Article