Research of Anticancer Realgar Preparations from Perspective of Patent / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae
; (24): 226-234, 2020.
Article
in Zh
| WPRIM
| ID: wpr-872721
Responsible library:
WPRO
ABSTRACT
To review the research progress of anticancer realgar preparations from the perspective of patent,in order to provide a reference for the research of new antitumor realgar drugs. IncoPat database was retrieved with keywords plus IPC classification number. Original data and 72 patents of anti-cancer realgar preparations were obtained and included after artificial denoising. The quantitative analysis was made on the information about application trends,application types and patentee. The technical points of representative patents were summarized. ① The patent types of anticancer realgar preparations are mainly product patents. Its technological innovation has undergone the development of realgar compound agents,arsenic sulfide single agents,nanometer products of realgar agents,bioleaching of realgar preparations,compound realgar extract preparations,compound nano realgar preparations and arsenic sulfide polymorphic crystalline structure. ② Nano realgar agents, realgar bioleaching preparations, new crystalline type realgar preparations and realgar compound preparations. ③ The following studies should be strengthened in the future,involving the comparison of biological effects and toxicity of nano realgar preparations of different preparation processes,the selection of optimal particle size,the druggability of realgar bioleaching preparations,the discovery of new As4S4 crystalline forms and the secondary development of anticancer realgar preparations.
Full text:
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Experimental Traditional Medical Formulae
Year:
2020
Type:
Article