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Relationship Between Immune Checkpoint and Autoimmune Disease / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 188-195, 2020.
Article in Chinese | WPRIM | ID: wpr-872907
ABSTRACT
The normal immune system has the ability to distinguish between "self" and "non-self". Because of its dynamic balance of "immune activity-immune tolerance", it will produce immune response to the non-self antigen, but with no response or weak response to the self-antigen. However, if the balance was broken, T cell in the abnormal immune activation state will respond continually to the self-antigen, with an abnormal immune response, which caused autoimmune disease. Pathologically, "invalid" immune recognition and immune response become the main causes for autoimmune diseases. Co-stimulatory molecule is an important link between Attach antigen presenting cells(APC) and immune cells (T cell and B cell). Studies have proved that excessive co-stimulation and/or insufficient co-inhibition could cause detect of self-tolerance and induce autoimmunity. Although co-stimulatory and co-inhibitory pathways have a significant impact on all ADS, this paper focuses on their effect on two systemic autoimmune diseases [systemic lupus erythematosus (SLE) and rheumatoid arthritis(RA)] and two organ-specific autoimmune diseases [multiple sclerosis (MS) and type 1 diabetes (T1DM)], in order to discuss the pathogenesis and relationship between co-stimulatory molecules and autoimmune diseases.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2020 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2020 Type: Article