Anti-breast Cancer Mechanism of Active Ingredients of Traditional Chinese Medicine in Vitro / 中国实验方剂学杂志

ABSTRACT

Breast cancer mainly occurs in woman's mammary epithelial tissues, with a complex and unclear pathogenesis. The mortality rate is high and increasing year by year, and the patients become younger and younger, which seriously threatens woman's health. Therefore, it's urgent to find high-efficiency and low-toxicity medicines against breast cancer. The breast is not an essential organ for life support, but the cancer cells can easily fall off and metastasize throughout the body with blood or lymph fluid. It's a main cause of death. Surgery, radiotherapy, chemotherapy, molecular targeting, endocrine therapy, immunity therapy have certain limitations due to serious toxicity and side effects and the difficulty in controlling the invasion and metastasis of the cancer cell. In recent years, traditional Chinese medicine（TCM）has been widely studied and valued by researchers at home and abroad due to its unique advantages, such as multiple pathways, multiple targets, low toxicity and fewer side effects, and a lot of TCMs and their active ingredients with the anti-breast cancer activity have been studied by the researchers. Based on flavonoids, polyphenols, alkaloids, terpenes and other TCM ingredients, the mechanism in inhibiting breast cancer cell proliferation, inducing it apoptosis, inhibiting it invasion and migration in vitro were taken as the main content, which was supplemented by the summary of main relevant signal pathways targeted by the ingredients. This study reviewed the mechanism of ingredients in suppressing breast cancer in vitro by viewing and screening relevant literature at home and abroad in the past 10 years. The in-depth study of effective ingredients of TCM is expected to provide a reference for the development of effective targeting preparations for treating breast cancer. On the basis of in-depth excavation of active ingredients of TCM, relevant studies in the future are suggested to apply the ingredients of TCM acting on the same or similar pathways, factors, proteins, and make use of the basic theory of TCM, so as to achieve the effect in against breast cancer.