Effects of c -Fos Immunoreactivity on Central Nervous System after Administration of Aspirin / 체질인류학회지
Korean Journal of Physical Anthropology
; : 17-27, 2001.
Article
in Ko
| WPRIM
| ID: wpr-87297
Responsible library:
WPRO
ABSTRACT
Aspirin is one of the popular non -steroid anti -inflammatory drugs used in the management of pain. This study was performed to investigate the effects of aspirin on c -Fos expression in rat CNS after inducing somatic pain with formalin. Male S.D. rats were injected subcutaneously with 0.1 ml of 5% formalin in the plantar surface of right hindpaw. For experimental group, aspirin was administered orally before injection of formalin. Asprin -untreated group was utilized as the control group. Rats were sacrificed at 0.5, 1, 2, 6 and 24 hours after formalin injection. Rat brains were removed and sliced in rat brain matrix. Brain slices were coronally sectioned at interaural 5.70 ~6.70 mm. Serial sections were immunohisto-chemically reacted with polyclonal c -Fos antibody. The numbers of c -Fos protein immunoreactive neurons in the cingulate cortex, primary somatosensory area, and hippocampus were counted and analyzed statistically with Mann - Whitney U test. Results were as follows: 1. Higher numbers of c -Fos immunoreactive neurons were found in the cingulate cortex, primary somatosensory area and hippocampus. 2. Both aspirin -treated and -untreated groups, numbers of c -Fos immunoreactive neurons were significantly higher all time points than formalin -untreated group, which peacked at 2 hours. 3. The numbers of c -Fos immunoreactive neuron of the aspirin -treated group were less compared to the aspirin - untreated group at each time point. In conclusion, these results provide some basic knowledge in understanding the mechanism and control of formalin - induced somatic pain.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Brain
/
Central Nervous System
/
Aspirin
/
Nociceptive Pain
/
Formaldehyde
/
Gyrus Cinguli
/
Hippocampus
/
Neurons
Limits:
Animals
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Humans
/
Male
Language:
Ko
Journal:
Korean Journal of Physical Anthropology
Year:
2001
Type:
Article