Clinical Efficacy of Ditantang on Pediatric Epilepsy with Phlegm and Stasis-type Tonic-clonic Seizure and Its Effect on Immunoglobulin, Peripheral Blood Th17 Cells and Relevant Factors / 中国实验方剂学杂志

ABSTRACT

Objective:To observe the clinical efficacy of Ditantang on phlegm turbid-blocked obstruction type tetan-burst twins in children with epilepsy and its effect on immunoglobulin, Peripheral blood helper T cells 17（Th17）， interleukin-6 (IL-6) and interleukin-17A（IL-17A）in children with epilepsy. Method:The random distribution sequences of 100 children generated by the random number table method were placed in sealed envelopes, and the subjects were divided into the corresponding experimental group and treatment group. Control group was treated with sodium valproate oral solution, and treatment group was also treated with Ditantang in addition to the therapy of control group. The total course of treatment was 3 months. The changes of immunoglobulin M（IgM）， immunoglobulin A（IgA），immunoglobulin G（IgG）, peripheral blood Th17 cells，IL-6，IL-17A, C-reactive protein (hs-CRP), blood homocysteine (Hcy) and the adverse reactions were detected before and after treatment in two groups. The changes in the number of seizures, duration of seizures and EEG before treatment and 3 months after treatment were compared between the two groups. Result:Three months after the treatment of phlegm-blocking obstruction type tetan-burst twin epilepsy with Ditantang combined with sodium valproate, the results showed that the total effective rate of treatment group was superior to that of control group, with statistically significant differences (P<0.05). After treatment, treatment group was superior to control group in the reduction of epilepsy score (P<0.05). Compared with before treatment, the levels of IgG，IgA and IgM in treatment group were significantly increased (P<0.05), while the levels of Th17，IL-6，IL-17A，hs-CRP and Hcy in peripheral blood were significantly decreased. Compared with control group, the levels of Th17，IL-6，IL-17A，hs-CRP and Hcy in peripheral blood decreased significantly after treatment (P<0.05). The incidence of adverse reactions in control group was significantly higher than that in treatment group (P<0.05). Conclusion:Ditantang is effective and safe in treating phlegm turbidness and obstruction type epilepsy (tetan-episode twin), and can improve the clinical symptoms of children and electroencephalogram. Besides, it can improve the level of immunoglobulin in children, significantly reduce the levels of Th17，IL-6 and IL-17A in their peripheral blood, regulate the immune function of the body, and reduce the incidence of adverse reactions.