Effect of Modified Qingzao Jiufei Tang on Quality of Life and Survival Period of Patients with Non-small Cell Lung Cancer / 中国实验方剂学杂志

ABSTRACT

Objective:To discuss the efficacy of modified Qingzao Jiufei Tang combined with adjuvant chemotherapy on quality of life and survival period of patients with non-small cell lung cancer (NSCLC) and the moderation effect on immune function and cytokines. Method:One hundred and twenty patients were randomly divided into control group (60 cases) and observation group (60 cases) by random number table. Patients in two group got paclitaxel and cisplatin chemotherapy.The control group took Yifei Qinghua granules orally,2 bags/time,3 times/day. In addition to the therapy of control group, patients in observation group were added with modified Qingzao Jiufei Tang from the first day after chemotherapy to the 12th week after chemotherapy, 1 dose/day. Six-month and one-year survival rates and survival period were recorded. Before and after treatment, lung cancer quality of life scale (FACT-L 4.0) and M.D. Anderson Symptom Inventory (MDASI-C) were scored. And levels of CD3+, CD4+, CD8+ and CD4+/CD8+ , natural killer cells (NK), cytokeratin 19 fragment 21-1 (CYFRA21-1), squamous cell carcinoma antigen (SCC-Ag), neuron-specific enolase (NSE), vascular endothelial growth factor (VEGF), nuclear transcription factor-κB (NF-κB), intercellular adhesion molecule 1 (ICAM-1), transforming growth factor (TGF)-β1 were all detected. Result:The 6-month survival rate of in observation group was 78.33%(47/60), which was higher than 60.00%(36/60) in control group (χ2=4.728, P<0.05). The one-year survival rate in observation group was 48.33%(29/60), which was higher than 30.00%(18/60) in control group (χ2=4.232, P<0.05). And the survival period in observation group was 15 months, which was longer than 11 months in control group (P<0.01). And scores of FACT-L and various factors were all higher than those in control group (P<0.01). Scores of disease symptoms, gastrointestinal symptoms, fatigue symptoms and emotional symptoms were all lower than those in control group (P<0.01), and scores of effect of symptoms on daily life in six aspects, such as enjoyment of life, were all lower than those in control group (P<0.01). And levels of NK, CD3+, CD4+ and CD4+/CD8+ were higher than those in control group (P<0.05), while levels of CD8+, TGF-β1, NF-κB, ICAM-1, VEGF, CYFRA21-1, SCC-Ag and NSE were all lower than those in control group (P<0.01). Conclusion:Modified Qingzao Jiufei Tang combined with adjuvant chemotherapy can prolong the survival time, improve the survival rate, alleviate the effect of symptoms on daily life, improve the quality of life, inhibit the expression of tumor markers and cytokines, and stabilize the immune function of the body, with a positive clinical significance in improving the prognosis of NSCLC.