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Role of NLRP3 inflammasome and related inflammatory signaling pathways in renal ischemia-reperfusion injury / 器官移植
Organ Transplantation ; (6): 177-2021.
Article in Zh | WPRIM | ID: wpr-873727
Responsible library: WPRO
ABSTRACT
Renal ischemia-reperfusion injury (IRI) commonly occurs in renal transplantation, which is an important pathophysiological process that causes acute renal failure and severely affects clinical prognosis of the recipients. Inflammatory response plays a critical role in the pathogenesis and pathological process of IRI. Activated NOD-like receptor protein 3(NLRP3) inflammasome can mediate the maturation and release of various pro-inflammatory cytokines, thereby regulating the inflammatory response and relevant cell functions. In this article, the mechanism underlying NLRP3 inflammasome and its related inflammatory signaling pathway in renal IRI were reviewed, aiming to provide novel ideas for clinical prevention and treatment of renal IRI.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Organ Transplantation Year: 2021 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Organ Transplantation Year: 2021 Type: Article