Prostate-specific Antigen Density: Correlation with Prostatic Histological Composition in Men with Benign Prostatic Hyperplasia / 대한비뇨기과학회지

ABSTRACT

PURPOSE: Pretreatment knowledge of prostate gland histology may help to select medical therapy for men with benign prostatic hyperplasia(BPH). Our objective was to determine whether prostate-specific antigen density(PSAD) correlated to the relative amount of epithelium in BPH tissue. MATERIALS AND METHODS: We evaluated 32 men with pathologically proven BPH who underwent transurethral resection of the prostate. All clinical findings which were age, symptom scores, maximal flow rate, total serum PSA, PSAD, prostate volume, transitional zone volume, transitional zone ratio were correlated with mean epithelial score(MES), which measures semi-quantitatively to represent the relative amount of epithelium in the resected BPH tissues. RESULTS: Prostatic size, serum PSA and PSAD showed significant correlation with MES in univariate analysis, but multivariate analysis showed that only PSAD was statistically significant(p<0.05). CONCLUSIONS: These data suggest that PSAD be related to the histological composition of the prostate in men with BPH. Therefore it might be useful as an evaluation to direct BPH therapy.