Organoid Model in Idiopathic Pulmonary Fibrosis
International Journal of Stem Cells
;
: 1-8, 2021.
Article
in English
| WPRIM
| ID: wpr-874632
ABSTRACT
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive- fibrosing disease characterized by extensive deposition of extracellular matrix (ECM), scarring of the lung parenchyma. Despite increased awareness of IPF, etiology and physiological mechanism of IPF are unclear. Therefore, preclinical model will require relevant and recapitulative features of IPF. Recently, pluripotent stem cells (PSC)-based organoid studies are emerging as an alternative approach able to recapitulate tissue architecture with remarkable fidelity. Moreover, these biomimetic tissue models can be served to investigate the mechanisms of diverse disease progression. In this review, we will overview the current organoids technology for human disease modeling including lung organoids for IPF.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
International Journal of Stem Cells
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS