Implications of Adult Neural Stem Cell Abnormalities in the Pathophysiological Mechanism of Schizophrenia / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 28-35, 2021.
Article
in English
| WPRIM
| ID: wpr-874780
ABSTRACT
Schizophrenia is a syndrome involving positive symptoms, negative symptoms, and cognitive decline due to several causes. The neuropathological findings of schizophrenia are unclear, but the age of onset of schizophrenia is consistent from the late teens to twenties, and patients with schizophrenia usually have prodromal symptoms. Research on schizophrenia is ongoing according to the neurodevelopmental hypothesis. Neural stem cell abnormalities are suggested to affect the pathophysiology of schizophrenia through brain imaging studies, genomic studies, and postmortem brain studies in patients with schizophrenia and are consistent with the existing striatumcentered dopamine hypothesis. This paper briefly introduces neural stem cells, particularly adult neural stem cells, and striatal abnormalities and explains their effects on the pathophysiology of schizophrenia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
English
Journal:
Journal of Korean Neuropsychiatric Association
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS