Immunomodulatory effect of beta-glucan derived from Saccharomyces cerevisiae strains / 동물의과학연구지
Journal of Biomedical Research
; : 23-27, 2013.
Article
in Ko
| WPRIM
| ID: wpr-87603
Responsible library:
WPRO
ABSTRACT
The aim of this study was to evaluate immunopotentiating activities of beta-glucan derived from Saccharomyces (S.) cerevisiae and to select new strains having possibility as an immune-enhancing substance. We examined SB20 strains derived from commercial product as a control, and extracted beta-glucans from the four strains of S. cerevisiae. RAW264.7 macrophages were treated with heat-killed yeasts, beta-glucans, and lipopolysaccharide (LPS). The production of nitric oxide (NO) and cytokines such as TNF-alpha and IL-1beta were then quantified. When macrophages were induced directly by in vitro addition of beta-glucan, little production of NO and IL-1beta was observed. When pretreated with strong stimulants, i.e., LPS, most yeasts showed down-modulation of NO and IL-1beta production. However, TNF-alpha secretion was triggered by beta-glucans and even more increased by the mixture effect of LPS and beta-glucans. In particular, S6 strain induced TNF-alpha secretion more than other strains. Therefore, we can conclude that the S6 strain has possibility as an immune-enhancing substance.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Saccharomyces
/
Saccharomyces cerevisiae
/
Sprains and Strains
/
Yeasts
/
Cytokines
/
Tumor Necrosis Factor-alpha
/
Beta-Glucans
/
Macrophages
/
Nitric Oxide
Language:
Ko
Journal:
Journal of Biomedical Research
Year:
2013
Type:
Article